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I have to strongly agree with nobody’s bottom line assessment on this. Is diet a very influential cog to unlocking the mystery of the ‘gout in some humans and some not’ conundrum ???
@ Colin Purves. I can not answer that question, I wish I could.. My hope is that regular intake of malic acid is dissolving the excess uric acid that my body can’t handle, before it has a chance to accumulate and cause problems. Can that process actually take place in the human body. ? If that is the case then one would think that it would result in a lower UA blood count, not higher ?. If it is effective. is long term use of malic acid safe ? Intriguing yes. A lot of unknowns for sure. For me, one gout-free day at a time.
I guess I’d better quickly chime in here.. You guys seem quite a bit more knowledgeable than myself on the mysteries of gout and it’s treatment, and that’s why I love this site. It’s a great source of learning on the subject. Anyway I had resent bloodwork done, 9-20-2017, and my uric acid was a whopping 8.0. Up from 7.6 and 6.9 over the last 7 months.?? But no flare-ups or attacks of any kind in that time frame. I have radically changed my diet. No meat, (animal flesh of any kind), and no high fructose corn syrup. And now drink only water, coffee, and beer, in that order. Supplements have been, L-malic acid, 600 mg cap and apple cider vinegar,450 mg cap, per day over that same time period. My question is the same as yours. Why have I had no attacks or trouble after having them regularly for the last 8 years, and currently having that high of a UA count. ? I wish I had that answer but I don’t. Is it the supplements ? Is it the diet? Is it both ? Don’t know…. What I do know is that I have been gout attack free for 7 months now, so I’m just going to keep on doing what I’m doing and stay on that road to see where it leads . Good luck to all….
Wow! Your description of your finger gout makes me shudder As I have had the same affliction in my middle finger, last joint just below the nail. Because of the incredible pain. I actually had to go to the E-R for analysis. They’re conclusion was a bone infection, then treated with a plethora of unneeded antibiotics, which did nothing because it was gout related tophi that they saw as a bacterial infection.. That joint is still misshapen, but I have had no day to day issues with it at all. I have been gout flair-up and attack free for 6 months now through supplements and diet, (no meds). I will post more on that very soon. Stay healthy…
Rich, Also worth a read and a ‘hill of beans’, good luck…
Urate Oxidase (Uricase)Hi Rich, You might want to read this as it could be helpful to you, as it was for myself and my gout problems. It does get a bit technical, but It may have some insights to some of your earlier questions.
[admin: link updated to more recent report]
Lu, Li-juan, Ning-Bo Hao, Jian-Jun Liu, Xue Li, and Rui-Ling Wang. “Correlation between Helicobacter pylori Infection and Metabolic Abnormality in General Population: A Cross-Sectional Study.” Gastroenterology research and practice 2018 (2018).In this study, we revealed that H. pylori infection was in association with uric acid
Also:
Ndebi, M. E. “The assessment of risk factors, lipid profile, uric acid and alanine aminotransferase in Helicobacter pylori-positive subjects.” International Journal 6, no. 9 (2018): 2889.Our study therefore suggests that H. pylori infection can cause modifications of lipid parameters and uremia that are considered as risk factors for cardiovascular diseases and gout. […] our data showed that H. pylori infection significantly modified serum uric acid level. Previous studies demonstrated that chronic H. pylori infection involves significant increase in uric acid serum level
Is colchicine really effective to relieve gout symptoms?
I am assuming that it must be since there are so many people using it. After a quick online Wikipedia (Wiki) inquiry about it though, I must say that I am a bit skeptical about its safety and its necessity for gout treatment.
I was getting flare ups about every 4-6 weeks regularly, with some of them leading to full blown attacks where I would have to miss work for a week. Usually in one of my feet, sometimes on top of the foot? Also in my finger joints, the last joint below the fingernail. Always very painful as you may know. Hope this helps.
@d q. I started taking one sometimes two 600 mg capsules of L-malic acid a day since March 2017, along with apple cider vinegar and celery seed extract caps [Celery Seed for Gout Forum linked above]. Only had uric acid checked once since then, late July-17, and it actually went up, from 6.9 to 7.6. No doubt quite high. I can’t explain that but it was suggested that it could be related to the ongoing break down of uric acid crystals still in the blood? I have been basically symptom-free. With no flare-ups or gout attacks since then, March 2017. Is that supplement related? I don’t know for sure. I am just trying to stay away from prescribed meds for as long as possible. There doesn’t seem to be much research out there on malic acid for treatment of gout but there is some. Here is one informative site on malic acid itself. Good luck…. https://thedailyhealth.co.uk/malic-acid-chronic-fatigue-syndrome-00974/
As far as an herbal alternative, I would highly recommend Malic acid,(Apple acid) supplements. Combined with Apple cider vinegar,(ACV) supplements, daily, to relieve and possibly eliminate gout pain and flare-ups. The research for that may not be out there, but the success stories are there if you look. Good Luck to you….
The debate here is over. Stay healthy and may your tophi lose there grip forever.
I will however periodically check back with any relevant info pertinent to my placebo therapy.I apologize, I certainly didn’t mean to offend anyone in any way. I suppose that I should have stated it more clearly. “How can the consumer cost of that therapy possibly be justified by the pharmaceutical company that markets it”. R&D etc. I also did suggest that malic acid supplementation therapy may possibly be “any other way” to successfully treat bone and joint damaging gout tophi. Simply another option to weigh for those suffering with gout. Let me also add that I am a long time gout sufferer, 10yrs, but I so far have not used any prescription drugs for treatment. I do have substantial damage to some finger and toe joints and have had many crippling attacks. Supplements are all that I have used thus far and malic acid has been instrumental in keeping my gout at bay. Just the facts…
I forgot to add this interesting link. https://en.wikipedia.org/wiki/Savient_pharmaceuticals
John Temple
Am I reading this correctly?, “Krystexxa is not $5,000/mo USD. It was about $65,000/mo. The total cost of my 6 month infusion treatment was almost $400,000”?? Wow! So that’s only about $800,000,?? (Eight hundred thousand) U.S. dollars a year to treat the worst case scenario of chronic gout. How can the cost of that therapy possibly be justified, ?? I ‘me all ears. Go ahead….nobody
“Malic acid clearly doesn’t do what pegloticase does. You should know since you’ve tried”. “Excuse me”, I don’t believe that I ever mentioned any comparisons to either or… All that I have stated is that with daily oral malic acid supplementation. I have had no gout attacks at all since my last foot attack, March, 2017. My only conclusion is that I believe through the mechanism of dissolving uric acid before it can crystalize, It no longer posses a threat to the joints. I am not a chemist and I can not explain how malic-A does this or how Krystexxa, (pegloticase) does it either. I am just a long time gout sufferer who wishes to become Gout-Free…Hmmm, Kyrstexxa at about $5000 U.S. dollars a month. Malic acid caps at about $20 a month. Gosh darn, do I smell Big-Pharma here ??? I know that the research isn’t in yet on Malic-A, or is it, but why would you not try one before the other? Knowledge is Power. Stay gout free….
I am not a doctor nor a specialist, and only speak from my own personal research conducted on myself.. I believe that you can liquefy uric tophi with malic acid, but then that liquefied substance must be carried out of the body. There in lies the problem witch needs further research. I was also diagnosed by an orthopedic surgeon with the same condition in one of my finger joints. I opted to have no surgery done, and since then, (with daily malic acid supplementation), I have had NO gout flare ups at all.. Just the Facts. Hope this helps…